MiR-9 inhibits proliferation of breast cancer cells
نویسندگان
چکیده
Background: Dysregulation of miRNAs is associated with breast cancer. Results: MiR-9 overexpression and transcriptome analysis reveals novel miR-9 targets, including MTHFD2, which can recapitulate anti-proliferative effects of miR-9 overexpression. Conclusion: MiR-9 displays tumor-suppressor like activity in breast cancer cells, MTHFD2 contributes to this activity. Significance: Understanding miR-9 directed regulation of the breast cancer transcriptome is important for diagnosis and therapeutics.
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تاریخ انتشار 2012